⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750170 | 0.87 | — | — | |
| SCHEMBL1750613 | 0.87 | — | — | |
| SCHEMBL1749541 | 0.86 | — | — | |
| SCHEMBL1975822 | 0.84 | — | — | |
| SCHEMBL14074203 | 0.56 | APLNR (0.32) | — | |
| SCHEMBL8449083 | 0.48 | APLNR (0.32) | — | |
| SCHEMBL12252323 | 0.48 | — | — | |
| SCHEMBL887222 | 0.48 | ADH1A (0.32) | — | |
| SCHEMBL823159 | 0.48 | ADH1A (0.32) | — | |
| SCHEMBL11917717 | 0.48 | APLNR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | claimed |
| US-20220143001-A1 | NOVEL PAN-RAF KINASE INHIBITOR AND USE THEREOF | Tarapeutics Science Inc. (CN) | 2022-05-12 | — | — | US | claimed |
| EP-3932913-A1 | NEW-TYPE PAN-RAF KINASE INHIBITOR AND USE THEREOF | Tarapeutics Science Inc. (CN) | 2022-01-05 | — | — | EP | claimed |
| US-20200325156-A1 | HETEROARYL AMIDE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF | RUI JIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2020-10-15 | — | — | US | claimed |
| EP-3705481-A1 | HETEROARYL AMIDE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF | Rui Jin Hospital Affiliated To Shanghai Jiao Tong University School of Medicine (CN) | 2020-09-09 | — | — | EP | claimed |
| US-20200109122-A1 | SUBSTITUTED IMIDAZOLE SALT COMPOUNDS, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | XIAMEN VIVOHEALTHS TECHNOLOGY CO., LTD. (CN) | 2020-04-09 | — | — | US | claimed |
| EP-3608312-A1 | SUBSTITUTED IMIDAZOLE SALT COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | Xiamen Vivohealths Technology Co., Ltd. (CN) | 2020-02-12 | — | — | EP | claimed |
| US-20070293547-A1 | Compounds and Compositions as Lxr Modulators | IRM LLC (BM) | 2007-12-20 | — | — | US | claimed |
| EP-3608312-B1 | SUBSTITUTED IMIDAZOLE SALT COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | XIAMEN VIVOHEALTHS TECH CO LTD (CN) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |
| US-20230202986-A1 | SUBSTITUTED IMIDAZOLE SALT COMPOUNDS, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF | XIAMEN VIVOHEALTHS TECHNOLOGY CO., LTD. (CN) | 2023-06-29 | — | — | US | disclosed |
| US-11584722-B2 | Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof | XIAMEN VIVOHEALTHS TECHNOLOGY CO., LTD. (CN) | 2023-02-21 | — | — | US | disclosed |
| US-20200325156-A1 | HETEROARYL AMIDE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF | RUI JIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2020-10-15 | — | — | US | disclosed |
| EP-3705481-A1 | HETEROARYL AMIDE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF | Rui Jin Hospital Affiliated To Shanghai Jiao Tong University School of Medicine (CN) | 2020-09-09 | — | — | EP | disclosed |
| EP-1713465-A4 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2009-04-22 | — | — | EP | disclosed |
| US-20070293547-A1 | Compounds and Compositions as Lxr Modulators | IRM LLC (BM) | 2007-12-20 | — | — | US | disclosed |
| EP-1713465-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005077122-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | disclosed |
| US-4260624-A | Fungicidal 2-substituted-3-oxa-3a lambda4,4-dithia-6-chloro-1,5-diazapentalene | CHEVRON RESEARCH COMPANY (US) | 1981-04-07 | — | — | US | disclosed |
| US-3983126-A | SEDATIVES | DUFOUR CLAUDE | 1976-09-28 | — | — | US | disclosed |