Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6318009 | 0.84 | CTSS (0.57) | KMT2AACEMMECPA1ACE2 | |
| SCHEMBL27563011 | 0.84 | CTSS (0.57) | KMT2AACEMMECPA1ACE2 | |
| SCHEMBL3026223 | 0.83 | ACE (0.54) | ACEMMEACE2ITGA4ITGB7 | |
| SCHEMBL2476918 | 0.83 | ACE (0.54) | ACEMMEACE2ITGA4ITGB7 | |
| SCHEMBL3268059 | 0.83 | ACE (0.54) | ACEMMEACE2ITGA4ITGB7 | |
| SCHEMBL6170513 | 0.82 | ACE (0.57) | KMT2AACEMMECPA1ACE2 | |
| SCHEMBL503474 | 0.82 | ACE (0.57) | KMT2AACEMMECPA1ACE2 | |
| SCHEMBL6317207 | 0.78 | CTSS (0.58) | ACECTSSCTSK | |
| SCHEMBL8553442 | 0.78 | ACE (0.61) | KMT2AACECTSSCTSKMAPT | |
| SCHEMBL7434878 | 0.78 | ACE (0.61) | KMT2AACECTSSCTSKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054402-B1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | MERCK SHARP & DOHME (NL) | 2013-11-27 | — | — | EP | disclosed |
| US-8299091-B2 | Aminoisoquinoline thrombin inhibitor with improved bioavailability | MSD OSS B.V. (NL) | 2012-10-30 | — | — | US | disclosed |
| US-20100305153-A1 | AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305153-A1 | AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | TFPI, TFPI2, PREP | KMT2A 1386/4885ACE 105/4885MME 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.