Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.72 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.72 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.72 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.72 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.72 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.72 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.66 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.66 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.66 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.66 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.66 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.66 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.66 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403330 | 0.85 | F2 (1.00) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL377181 | 0.84 | CHRNA7 (0.55) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL8106249 | 0.81 | F2 (0.89) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL12355710 | 0.79 | F2 (1.00) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL3555044 | 0.79 | F2 (0.85) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL376845 | 0.79 | USP2 (0.60) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL26474835 | 0.78 | F2 (0.78) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL10222721 | 0.77 | MGLL (0.43) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL10222720 | 0.77 | MGLL (0.46) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL18937140 | 0.77 | MAPT (0.59) | F2PRSS1PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765778-B1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES | 2010-02-11 | — | — | US | disclosed |
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES | 2010-02-11 | — | — | US | disclosed |
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES | 2010-02-11 | — | — | US | disclosed |
| US-7585858-B2 | N-sulfonylcarboximidamide apoptosis promoters | ABBOTT LABORATORIES (US) | 2009-09-08 | — | — | US | disclosed |
| EP-1765778-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005117543-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | ABBVIE INC. | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | BAX, BCL2, BAD | F2 4874/4885PRSS1 944/4885PRSS2 1637/4885 |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | BAX, BCL2, BAD | F2 4874/4885PRSS1 944/4885PRSS2 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.