Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014834 | 0.94 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3014399 | 0.94 | MEN1 (0.48) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3015184 | 0.89 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3013621 | 0.89 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3012142 | 0.89 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3010628 | 0.89 | L3MBTL1 (0.50) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3652439 | 0.88 | POLB (0.46) | MEN1KMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3002593 | 0.88 | MEN1 (0.46) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3004887 | 0.87 | MEN1 (0.47) | MEN1KMT2AALDH1A1TSHRATM | |
| SCHEMBL3017970 | 0.87 | MEN1 (0.50) | MEN1KMT2AALDH1A1TSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |