Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | P4HB | P07237 | 2/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27840729 | 0.91 | MAPT (0.47) | MAOBBCHEP4HBCYP1B1GAA | |
| SCHEMBL5324147 | 0.90 | MAPT (0.38) | MAOBBCHEP4HBCYP1B1NPC1 | |
| SCHEMBL27840781 | 0.88 | KMT2A (0.42) | MAOBBCHEP4HBCYP1B1RAB9A | |
| SCHEMBL27821480 | 0.87 | KMT2A (0.42) | MAOBBCHEP4HBCYP1B1GAA | |
| SCHEMBL27869381 | 0.87 | ALDH1A1 (0.43) | CYP1B1NPC1GAAHTTRAB9A | |
| SCHEMBL27821481 | 0.86 | MAOB (0.46) | MAOBBCHEL3MBTL1NPC1GAA | |
| SCHEMBL27840910 | 0.81 | POLB (0.38) | MAOBBCHEP4HBCYP1B1CA2 | |
| SCHEMBL3891559 | 0.80 | KAT6A (0.41) | MAOBBCHECYP1B1MAPT | |
| SCHEMBL28053743 | 0.80 | MAPT (0.36) | MAOBBCHECYP1B1NPC1RAB9A | |
| SCHEMBL27840804 | 0.80 | MAPT (0.35) | MAOBBCHECYP1B1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102199113-A | Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds | SNU R&DB FOUNDATION | 2011-09-28 | — | — | CN | claimed |
| US-20090252694-A1 | Novel Chalcone Derivatives, Pharmaceutically Acceptable Salt, Method for Preparation and Uses Thereof | INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSTIY (KR) | 2009-10-08 | — | — | US | claimed |
| WO-2007114532-A1 | NOVEL CHALCONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT, METHOD FOR PREPARATION AND USES THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) | 2007-10-11 | — | — | WO | claimed |
| CN-101528210-B | Method for screening anticancer compound inhibiting TM4SF5 function and anticancer composition containing chalcone compound | SEOUL NAT UNIV IND FOUNDATION | 2012-05-23 | — | — | CN | disclosed |
| CN-102199113-A | Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds | SNU R&DB FOUNDATION | 2011-09-28 | — | — | CN | disclosed |
| US-7851654-B2 | Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof | INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) | 2010-12-14 | — | — | US | disclosed |
| US-20090252694-A1 | Novel Chalcone Derivatives, Pharmaceutically Acceptable Salt, Method for Preparation and Uses Thereof | INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSTIY (KR) | 2009-10-08 | — | — | US | disclosed |
| WO-2007114532-A1 | NOVEL CHALCONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT, METHOD FOR PREPARATION AND USES THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090252694-A1 | Novel Chalcone Derivatives, Pharmaceutically Acceptable Salt, Method for Preparation and Uses Thereof | TYR, CYP21A2, CMA1 | MAOB 188/4885BCHE 375/4885P4HB 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.