Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3773025 | 1.00 | JAK2 (0.42) | JAK2MAPTAPPSNCASMN1; SMN2 | |
| SCHEMBL3771436 | 0.91 | NFE2L2 (0.44) | JAK2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3771439 | 0.91 | NFE2L2 (0.44) | JAK2MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3769153 | 0.88 | JAK2 (0.44) | JAK2MAPTSMN1; SMN2PDE5APOLB | |
| SCHEMBL3768714 | 0.88 | JAK2 (0.44) | JAK2MAPTSMN1; SMN2PDE5ACNR2 | |
| SCHEMBL3768711 | 0.88 | JAK2 (0.44) | JAK2MAPTSMN1; SMN2PDE5ACNR2 | |
| SCHEMBL3769148 | 0.88 | JAK2 (0.44) | JAK2MAPTSMN1; SMN2PDE5APOLB | |
| SCHEMBL3772605 | 0.87 | JAK2 (0.49) | JAK2MAPTPDE5APOLB | |
| SCHEMBL3772609 | 0.87 | JAK2 (0.49) | JAK2MAPTPDE5APOLB | |
| SCHEMBL416412 | 0.82 | JAK2 (0.48) | JAK2MAPTSMN1; SMN2PDE5APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170320870-A1 | COMPOUNDS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2017-11-09 | — | — | US | disclosed |
| EP-2408772-B1 | COMPOUNDS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2015-07-01 | — | — | EP | disclosed |
| US-20100317646-A1 | COMPOUNDS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-12-16 | — | — | US | disclosed |
| US-20100317646-A1 | COMPOUNDS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320870-A1 | COMPOUNDS | CBR3, CNR1, HCAR3 | JAK2 1557/4885MAPT 4568/4885APP 3905/4885 |
| US-20100317646-A1 | COMPOUNDS | CBR3, CNR1, HCAR3 | JAK2 1492/4885MAPT 4576/4885APP 3984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.