Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060122 | 0.81 | MAPT (0.63) | MAPTPOLBRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL17110620 | 0.74 | POLB (0.56) | MAPTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1266706 | 0.68 | TP53 (0.34) | MAPTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16147156 | 0.68 | TTK (0.46) | MAPTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17220221 | 0.67 | TSHR (0.53) | MAPTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16147157 | 0.67 | POLA1 (0.53) | RAB9ATTKCDK2 | |
| SCHEMBL30523365 | 0.67 | POLA1 (0.53) | RAB9ATTKCDK2 | |
| SCHEMBL17110632 | 0.67 | KCNH3 (0.51) | MAPTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2450994 | 0.67 | RAB9A (0.50) | MAPTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13395042 | 0.66 | TSHR (0.67) | MAPTPOLBRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122892-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122892-A1 | CHEMICAL COMPOUNDS | TP53, XPOT, KRAS | MAPT 1265/4885POLB 1755/4885RAB9A 872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.