Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3492352 | 0.90 | PDE5A (0.69) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL3492211 | 0.89 | PDE5A (0.67) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL3492213 | 0.88 | PDE5A (0.60) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL4518642 | 0.87 | PIP4K2A (0.66) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL38376 | 0.86 | RNASEH1 (0.52) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL38098 | 0.84 | PDE5A (0.56) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL37738 | 0.84 | PDE5A (0.56) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL16175769 | 0.82 | PDE5A (0.63) | PDE5AKMT2AALDH1A1KDM4EPIP4K2A | |
| SCHEMBL38743 | 0.82 | PDE5A (0.82) | PDE5AKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL37886 | 0.81 | PDE5A (0.59) | PDE5AKMT2AALDH1A1KDM4EPDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |