Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628244 | 0.79 | HTR6 (0.50) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL544207 | 0.78 | HTR6 (0.55) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL3520533 | 0.76 | CA1 (0.55) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6172350 | 0.76 | HTR6 (0.52) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL2412815 | 0.75 | F2 (0.55) | ALDH1A1LMNACA1CA2CA12 | |
| SCHEMBL7292002 | 0.74 | HTR6 (0.50) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL17808674 | 0.74 | HTR6 (0.50) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL2687422 | 0.74 | ALDH1A1 (0.52) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6717470 | 0.74 | HTR6 (0.50) | HTR6ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL9398028 | 0.74 | TSHR (0.52) | HTR6ALDH1A1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729954-B1 | Substituted thiophene sulfonyl ureas and thioureas, process for their preparation, their use as medicaments | HOECHST AG (DE) | 2003-09-03 | — | — | EP | claimed |
| EP-0729954-A1 | Substituted thiophene sulfonyl ureas and thioureas, process for their preparation, their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-09-04 | — | — | EP | claimed |
| EP-0590416-A1 | Substituted sulfonylureas as herbizides | BAYER AG (DE) | 1994-04-06 | — | — | EP | claimed |
| EP-2408760-A1 | THIOPHENYL SULFONAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Bristol-Myers Squibb Company (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20110071199-A1 | Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease | BRISTOL-MYERS SQUIBB COMPANY | 2011-03-24 | — | — | US | disclosed |
| WO-2010107997-A1 | THIOPHENYL SULFONAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-09-23 | — | — | WO | disclosed |
| EP-0942652-B1 | SUBSTITUTED THIENYL(AMINO)SULPHONYL(THIO)UREAS AS HERBICIDES | BAYER CROPSCIENCE AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| EP-0729954-B1 | Substituted thiophene sulfonyl ureas and thioureas, process for their preparation, their use as medicaments | HOECHST AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| EP-0942652-A1 | SUBSTITUTED THIENYL(AMINO)SULPHONYL(THIO)UREAS AS HERBICIDES | BAYER AG (DE) | 1999-09-22 | — | — | EP | disclosed |
| EP-0885216-A1 | SUBSTITUTED THIENYL SULPHONYL (THIO) UREAS AS HERBICIDES | BAYER AG (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1998025467-A1 | SUBSTITUTED THIENYL(AMINO)SULPHONYL(THIO)UREAS AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-18 | — | — | WO | disclosed |
| EP-0041404-B1 | HERBICIDAL THIOPHENESULFONAMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-01-30 | — | — | EP | disclosed |
| EP-0130109-A2 | Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-01-02 | — | — | EP | disclosed |
| US-4487951-A | INTERMEDIATES FOR PLANT GROWTH REGULATORS AND HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1984-12-11 | — | — | US | disclosed |
| US-4479821-A | HERBICIDES, PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1984-10-30 | — | — | US | disclosed |
| US-4443245-A | HERBICIDES, PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1984-04-17 | — | — | US | disclosed |
| US-4443243-A | HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1984-04-17 | — | — | US | disclosed |
| US-4425154-A | HERBICIDES, PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1984-01-10 | — | — | US | disclosed |
| US-4419121-A | HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0041404-A2 | Herbicidal thiophenesulfonamides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071199-A1 | Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease | APP, PSEN1, PSEN2 | HTR6 3309/4885ALDH1A1 1305/4885KDM4E 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.