Sugi Predict

Sugi Predict / Compounds / SCHEMBL377438

SCHEMBL377438

SCHEMBL377438

CN(/C=C/C=O)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CRHBP P24387 1/20 0.43
▸ CRHR2 Q13324 1/20 0.43
▸ ALDH1A1 P00352 6/20 0.41
▸ MEN1 O00255 4/20 0.41
▸ KMT2A Q03164 4/20 0.41
▸ MAPK1 P28482 3/20 0.41
▸ LMNA P02545 3/20 0.41
▸ HTT P42858 1/20 0.41
▸ TRPA1 O75762 1/20 0.41
▸ ALOX5 P09917 1/20 0.41
▸ ALOX15 P16050 4/20 0.39
▸ HPGD P15428 3/20 0.39
▸ MAPT P10636 2/20 0.39
▸ HSD17B10 Q99714 2/20 0.39
▸ USP2 O75604 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ GLA P06280 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL377439 1.00 CRHBP (0.43) CRHBPCRHR2ALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL9519074 0.98 CRHBP (0.42) CRHBPCRHR2ALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL9519072 0.98 CRHBP (0.42) CRHBPCRHR2ALDH1A1MEN1KMT2A
SCHEMBL3422813 0.92 CRHBP (0.41) CRHBPCRHR2ALDH1A1MEN1KMT2A
SCHEMBL3422816 0.92 CRHBP (0.41) CRHBPCRHR2ALDH1A1MEN1KMT2A
SCHEMBL5526432 0.77 MEN1 (0.48) ALDH1A1MEN1KMT2AMAPK1LMNA
SCHEMBL1332400 0.77 MEN1 (0.48) ALDH1A1MEN1KMT2AMAPK1LMNA
SCHEMBL66606 0.77 MEN1 (0.48) ALDH1A1MEN1KMT2AMAPK1LMNA
SCHEMBL29959966 0.77 MEN1 (0.48) ALDH1A1MEN1KMT2AMAPK1LMNA
SCHEMBL15215897 0.75 MEN1 (0.39) CRHBPCRHR2ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090648-A1 METHODS AND COMPOSITIONS FOR INHIBITING METASTASIS OF SOLID TUMORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-05-01 — — WO disclosed
EP-4065638-A1 PARTICULATE FILLER, PRODUCTION AND USE THEREOF Merck Patent GmbH (DE) 2022-10-05 — — EP disclosed
EP-3993813-A1 MODULATION OF T CELL CYTOTOXICITY AND RELATED THERAPY Cancer Research Technology Ltd. (GB) 2022-05-11 — — EP disclosed
US-20200263231-A1 Fluorogenic dyes for high sensitivity DNA detection Life Technologies Corporation 2020-08-20 — — US disclosed
EP-2408863-B1 NUCLEIC ACID BINDING DYES AND USES THEREFOR PROMEGA CORP (US) 2018-01-10 — — EP disclosed
US-9458499-B2 Nucleic acid binding dyes and uses therefor PROMEGA CORPORATION (US) 2016-10-04 — — US disclosed
US-9382425-B2 Aza-benzazolium containing cyanine dyes Life Technologies Corporation (US) 2016-07-05 — — US disclosed
US-20160083782-A1 NUCLEIC ACID BINDING DYES AND USES THEREFOR JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2016-03-24 — — US disclosed
US-9206474-B2 Nucleic acid binding dyes and uses therefor PROMEGA CORPORATION (US) 2015-12-08 — — US disclosed
US-20150031579-A1 Aza-Benzazolium Containing Cyanine Dyes MOLECULAR PROBES, INC. 2015-01-29 — — US disclosed
US-5436134-A Fluorescent dyes for nucleic acids MOLECULAR PROBES, INC. (US) 1995-07-25 — — US disclosed
WO-1994024213-A1 CYCLIC-SUBSTITUTED UNSYMMETRICAL CYANINE DYES MOLECULAR PROBES, INC. (US) 1994-10-27 — — WO disclosed
EP-0363934-B1 Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof SANDOZ AG (CH) 1993-12-29 — — EP disclosed
EP-0562643-A2 7-Substituted-hept-6-enoic and -heptanoic acids and derivatives thereof SANDOZ AG (CH) 1993-09-29 — — EP disclosed
US-5189043-A Useful as an inhibitory agent for the biosynthesis of cholesterol TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-02-23 — — US disclosed
EP-0480242-A2 Method for the production of alpha,beta-unsaturated carbonyl compounds BASF Aktiengesellschaft (DE) 1992-04-15 — — EP disclosed
EP-0424929-A1 Isoquinolone derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1991-05-02 — — EP disclosed
WO-1990003962-A1 PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED-HEPT-6-ENOIC AND -HEPTANOIC ACIDS AND DERIVATIVES AND INTERMEDIATES THEREOF SANDOZ AG (CH) 1990-04-19 — — WO disclosed
EP-0363934-A1 Process for the preparation of 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof SANDOZ AG (CH) 1990-04-18 — — EP disclosed
US-4239901-A ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1980-12-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200263231-A1 Fluorogenic dyes for high sensitivity DNA detection POLRMT, POLM, DNMT3A CRHBP 4244/4885CRHR2 4739/4885ALDH1A1 1423/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.