Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469304 | 0.78 | POLB (0.55) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL6032173 | 0.76 | MAPT (0.54) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL3774754 | 0.74 | MAPT (0.50) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL2085262 | 0.73 | MAPT (0.40) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL9545693 | 0.73 | MAPT (0.42) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL1269268 | 0.72 | MAPT (0.41) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL8857706 | 0.70 | KMT2A (0.52) | POLBMAPTGAATHRBALDH1A1 | |
| SCHEMBL8679131 | 0.68 | MAPT (0.41) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL28259783 | 0.68 | POLB (0.63) | POLBMAPTGAATHRBTP53 | |
| SCHEMBL8523889 | 0.66 | POLB (0.47) | POLBMAPTGAATHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451455-A2 | RXR AGONIST COMPOUNDS AND METHODS | Case Western Reserve University (US) | 2012-05-16 | — | — | EP | claimed |