SCHEMBL7469304

SCHEMBL7469304

COC1SC(=O)N(Cc2ccccc2)C1=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.55
MAPT P10636 5/20 0.50
THRB P10828 2/20 0.50
GAA P10253 1/20 0.50
TP53 P04637 1/20 0.49
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
ALDH1A1 P00352 6/20 0.46
ELANE P08246 2/20 0.46
F2 P00734 1/20 0.46
PLG P00747 1/20 0.46
CTSG P08311 1/20 0.46
CMA1 P23946 1/20 0.46
CTRC Q99895 1/20 0.46
GSK3A P49840 2/20 0.44
GSK3B P49841 2/20 0.44
EP300 Q09472 1/20 0.44
EHMT2 Q96KQ7 1/20 0.44
MGLL Q99685 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6032173 0.85 MAPT (0.54) POLBMAPTTHRBGAATP53
SCHEMBL3774750 0.78 POLB (0.46) POLBMAPTTHRBGAATP53
SCHEMBL3774754 0.77 MAPT (0.50) POLBMAPTTHRBGAATP53
SCHEMBL28259783 0.76 POLB (0.63) POLBMAPTTHRBGAATP53
SCHEMBL8523889 0.74 POLB (0.47) POLBMAPTTHRBGAATP53
SCHEMBL8576587 0.73 POLB (0.39) POLBMAPTTHRBGAATP53
SCHEMBL8687366 0.73 POLB (0.44) POLBMAPTTHRBGAATP53
SCHEMBL8471742 0.73 MAPT (0.41) POLBMAPTTHRBGAATP53
SCHEMBL8659796 0.72 MAPT (0.43) POLBMAPTTHRBGAATP53
SCHEMBL8571752 0.72 POLB (0.40) POLBMAPTTHRBGAATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214305-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP claimed
WO-2001016123-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO claimed
EP-0804193-A4 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS KURTZ THEODORE W (US) 2002-03-27 EP disclosed
EP-0804193-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-11-05 EP disclosed
WO-1995035108-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-12-28 WO disclosed