Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8333731 | 0.79 | PPARG (0.46) | MAPTTHRBGAAPOLBALDH1A1 | |
| SCHEMBL9545693 | 0.75 | MAPT (0.42) | MAPTTHRBGAAPOLBALDH1A1 | |
| Fumaric Acid SCHEMBL8337457 | 0.74 | PPARG (0.53) | MAPTTHRBGAAPOLBALDH1A1 | |
| SCHEMBL1269268 | 0.73 | MAPT (0.41) | MAPTTHRBGAAPOLBALDH1A1 | |
| SCHEMBL3774750 | 0.73 | POLB (0.46) | MAPTTHRBGAAPOLBALDH1A1 | |
| SCHEMBL8679131 | 0.72 | MAPT (0.41) | MAPTTHRBGAAPOLBALDH1A1 | |
| SCHEMBL4034343 | 0.72 | PPARG (0.46) | MAPTTHRBGAAALDH1A1CYP2C19 | |
| SCHEMBL7469304 | 0.71 | POLB (0.55) | MAPTTHRBGAAPOLBALDH1A1 | |
| SCHEMBL6032173 | 0.69 | MAPT (0.54) | MAPTTHRBGAAPOLBALDH1A1 | |
| SCHEMBL8472017 | 0.67 | POLB (0.45) | MAPTTHRBGAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973063-B2 | Methods for activating PPAR gamma-type receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-07-05 | — | — | US | disclosed |
| US-7863332-B2 | Biaromatic compound activators of PPARγ receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-04 | — | — | US | disclosed |