SCHEMBL377486

SCHEMBL377486

Cc1cc(=O)n(Cc2ccccc2)c2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
ATM Q13315 1/20 0.68
KDM4E B2RXH2 6/20 0.68
ALDH1A1 P00352 4/20 0.68
MAPT P10636 3/20 0.68
SMN1; SMN2 Q16637 2/20 0.68
MAPK1 P28482 1/20 0.63
HPGD P15428 1/20 0.61
GAA P10253 1/20 0.60
HSD17B10 Q99714 1/20 0.60
P2RX4 Q99571 2/20 0.60
CYP19A1 P11511 1/20 0.58
NQO2 P16083 1/20 0.56
LMNA P02545 1/20 0.51
NTRK1 P04629 1/20 0.50
PGR P06401 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30783416 1.00 MEN1 (1.00) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL5444674 0.89 MEN1 (0.81) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL12301952 0.88 MEN1 (0.78) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL16386559 0.88 MEN1 (0.78) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL12301950 0.86 MEN1 (0.75) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL9158213 0.84 MEN1 (0.72) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL15828754 0.83 MEN1 (0.70) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL30783430 0.83 KMT2A (0.70) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL29200844 0.83 KMT2A (0.70) MEN1KMT2AATMKDM4EALDH1A1
SCHEMBL388824 0.82 MEN1 (0.69) MEN1KMT2AATMKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117624043-A Preparation method of quinolinone compound 安徽中医药大学 2024-03-01 CN disclosed
EP-2408863-B1 NUCLEIC ACID BINDING DYES AND USES THEREFOR PROMEGA CORP (US) 2018-01-10 EP disclosed
EP-1885718-B1 FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE LIFE TECHNOLOGIES CORP (US) 2017-03-15 EP disclosed
US-9458499-B2 Nucleic acid binding dyes and uses therefor PROMEGA CORPORATION (US) 2016-10-04 US disclosed
US-9458499-B2 Nucleic acid binding dyes and uses therefor PROMEGA CORPORATION (US) 2016-10-04 US disclosed
US-9458499-B2 Nucleic acid binding dyes and uses therefor PROMEGA CORPORATION (US) 2016-10-04 US disclosed
US-9366676-B2 Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use Life Technologies Corporation (US) 2016-06-14 US disclosed
US-9366676-B2 Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use Life Technologies Corporation (US) 2016-06-14 US disclosed
US-20160083782-A1 NUCLEIC ACID BINDING DYES AND USES THEREFOR JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2016-03-24 US disclosed
US-20160083782-A1 NUCLEIC ACID BINDING DYES AND USES THEREFOR JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2016-03-24 US disclosed
WO-2010107816-A2 NUCLEIC ACID BINDING DYES AND USES THEREFOR PROMEGA CORPORATION (US) 2010-09-23 WO disclosed
US-20100233710-A1 NUCLEIC ACID BINDING DYES AND USES THEREFOR JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2010-09-16 US disclosed
US-20100233710-A1 NUCLEIC ACID BINDING DYES AND USES THEREFOR JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2010-09-16 US disclosed
US-20100233710-A1 NUCLEIC ACID BINDING DYES AND USES THEREFOR JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2010-09-16 US disclosed
US-20100143917-A1 FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE Life Technologies Corporation (US) 2010-06-10 US disclosed
US-20100143917-A1 FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE Life Technologies Corporation (US) 2010-06-10 US disclosed
US-7598390-B2 Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use Life Technologies Corporation (US) 2009-10-06 US disclosed
US-7598390-B2 Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use Life Technologies Corporation (US) 2009-10-06 US disclosed
US-4187310-A ANTIINFLAMMATORY AGENT, ANALGESICS, ENZYME INHIBITORS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-02-05 US disclosed
US-4138490-A Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic acid derivatives IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-02-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100233710-A1 NUCLEIC ACID BINDING DYES AND USES THEREFOR POLRMT, POLB, POLL MEN1 1703/4885KMT2A 3295/4885ATM 4098/4885
US-20100143917-A1 FLUORESCENT CHEMICAL COMPOUNDS HAVING HIGH SELECTIVITY FOR DOUBLE STRANDED DNA, AND METHODS FOR THEIR USE POLRMT, DNA2, NSUN2 MEN1 3097/4885KMT2A 1014/4885ATM 1613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.