Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 19/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18224106 | 0.85 | DHODH (0.49) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL6165007 | 0.82 | DHODH (0.48) | DHODH | |
| SCHEMBL4347338 | 0.82 | DHODH (0.53) | DHODHPDE10A | |
| SCHEMBL31490627 | 0.80 | ALDH1A1 (0.43) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL15491648 | 0.79 | DHODH (0.52) | DHODHDHFRALKBH5 | |
| SCHEMBL18225008 | 0.79 | AR (0.46) | DHODHPDE10A | |
| SCHEMBL8500781 | 0.75 | PDGFRB (0.49) | PDE10A | |
| SCHEMBL7027237 | 0.74 | ALDH1A1 (0.62) | DHODHDHFRALKBH5 | |
| SCHEMBL3894369 | 0.74 | DHODH (0.95) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL7698336 | 0.74 | DHODH (0.59) | DHODHDHFRALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873704-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20160333017-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2016-11-17 | — | — | US | disclosed |
| US-20100331306-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331306-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | DHODH 3116/4885DHFR 3942/4885ALKBH5 4267/4885 |
| US-20160333017-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | DHODH 3134/4885DHFR 3935/4885ALKBH5 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.