Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.43 |
| ▸ | CCR4 | P51679 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 3/20 | 0.37 |
| ▸ | TACR2 | P21452 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565979 | 1.00 | KCNH2 (0.46) | KCNH2CHRM4CCR4GPR119MCHR1 | |
| SCHEMBL3775698 | 0.91 | CCR4 (0.43) | KCNH2CHRM4CCR4CCR5MEN1 | |
| SCHEMBL2567955 | 0.91 | CCR4 (0.43) | KCNH2CHRM4CCR4CCR5MEN1 | |
| SCHEMBL2568654 | 0.86 | CCR4 (0.45) | KCNH2CHRM4CCR4GPR119CCR5 | |
| SCHEMBL3774851 | 0.86 | CCR4 (0.45) | KCNH2CHRM4CCR4GPR119CCR5 | |
| SCHEMBL3771103 | 0.84 | MEN1 (0.43) | CCR4MCHR1CCR5MEN1KMT2A | |
| SCHEMBL2563552 | 0.84 | MEN1 (0.43) | CCR4MCHR1CCR5MEN1KMT2A | |
| SCHEMBL2566009 | 0.82 | MEN1 (0.45) | CCR4MCHR1CCR5MEN1KMT2A | |
| SCHEMBL3771269 | 0.82 | MEN1 (0.45) | CCR4MCHR1CCR5MEN1KMT2A | |
| SCHEMBL2567462 | 0.81 | CCR4 (0.42) | CHRM4CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317644-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-16 | — | — | US | claimed |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2008-06-26 | — | — | US | claimed |
| US-8435978-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20100324009-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-23 | — | — | US | disclosed |
| US-20100317644-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-16 | — | — | US | disclosed |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317644-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | KCNH2 790/4885CHRM4 4163/4885CCR4 3875/4885 |
| US-20100324009-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | KCNH2 790/4885CHRM4 4163/4885CCR4 3875/4885 |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | SULT2A1, STS, SULT1A1 | KCNH2 790/4885CHRM4 4163/4885CCR4 3875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.