Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.54 |
| ▸ | LCK | P06239 | 4/20 | 0.54 |
| ▸ | TEK | Q02763 | 3/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.50 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31406748 | 1.00 | BRAF (0.54) | BRAFLCKTEKRAF1CSF1R | |
| SCHEMBL26209229 | 0.88 | RAB9A (0.43) | BRAFLCKTEKRAF1CSF1R | |
| SCHEMBL24399600 | 0.84 | RAF1 (0.54) | BRAFTEKRAF1CSF1RDDR1 | |
| SCHEMBL24399634 | 0.84 | FADS1 (0.54) | BRAFLCKRAF1CSF1RDDR1 | |
| SCHEMBL26373442 | 0.83 | RAF1 (0.52) | BRAFLCKRAF1TTBK1TTBK2 | |
| SCHEMBL3643334 | 0.82 | BRAF (0.52) | BRAFLCKTEKKDRTTBK1 | |
| SCHEMBL24399758 | 0.81 | BRAF (0.56) | BRAFLCKRAF1CSF1RDDR1 | |
| SCHEMBL29638619 | 0.81 | BRAF (0.56) | BRAFLCKRAF1CSF1RDDR1 | |
| SCHEMBL24399614 | 0.80 | ADORA2A (0.46) | BRAFLCKTEKRAF1CSF1R | |
| SCHEMBL26373249 | 0.80 | BRAF (0.40) | BRAFLCKTEKRAF1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140005198-A1 | RAF KINASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2014-01-02 | — | — | US | disclosed |
| US-8557830-B2 | RAF kinase modulators and methods of use | AMGEN INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20100324047-A1 | RAF KINASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324047-A1 | RAF KINASE MODULATORS AND METHODS OF USE | BRAF, RAF1, ARAF | BRAF 1/4885LCK 337/4885TEK 1825/4885 |
| US-20140005198-A1 | RAF KINASE MODULATORS AND METHODS OF USE | BRAF, RAF1, ARAF | BRAF 1/4885LCK 353/4885TEK 2109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.