SCHEMBL377713

SCHEMBL377713

O=C1CC(=O)ON1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8404671 0.73
SCHEMBL1897955 0.73 CRBN (0.40)
SCHEMBL11372080 0.71
SCHEMBL11377655 0.71
SCHEMBL11303741 0.67
SCHEMBL16883938 0.67
SCHEMBL8362367 0.65 CA1 (0.64)
SCHEMBL11381274 0.59
SCHEMBL1721066 0.59
SCHEMBL1487904 0.58

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 321 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2612858-A1 STAT3/5 activation inhibitor OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-07-10 EP claimed
US-20120238750-A1 AROMATIC COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. 2012-09-20 US claimed
US-20100210661-A1 STAT3/5 ACTIVATION INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2010-08-19 US claimed
US-20100004438-A1 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2010-01-07 US claimed
EP-2089373-A1 STAT3/5 ACTIVATION INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-08-19 EP claimed
EP-1957073-A2 MEDICINAL DRUG OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-08-20 EP claimed
WO-2008044667-A1 STAT3/5 ACTIVATION INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-04-17 WO claimed
US-20070270422-A1 Aromatic Compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-11-22 US claimed
WO-2007066784-A2 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-06-14 WO claimed
EP-1773797-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-04-18 EP claimed
WO-2006014012-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-02-09 WO claimed
WO-2000047209-A1 METHODS OF MODULATING URIC ACID LEVELS TULARIK INC. (US) 2000-08-17 WO claimed
US-4946963-A HYPOLIPIDEMIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1990-08-07 US claimed
EP-0321090-A2 Isoxazolidine-3,5-diones in the treatment of hyperlipidemia THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1989-06-21 EP claimed
JP-1258667-A None JP disclosed
EP-4674855-A1 A COMPOUND, AN ORGANIC LIGHT EMITTING DIODE COMPRISING THE DERIVATES, A USE OF THE DIODE, AND A CONSUMER PRODUCT Noctiluca S.A. (PL) 2026-01-07 EP disclosed
EP-4592297-A1 AN ORGANIC BORON COMPOUND, AN ORGANIC LIGHT EMITTING DIODE COMPRISING THE ORGANIC BORON COMPOUND, A USE OF THE DIODE, AND A CONSUMER PRODUCT Noctiluca S.A. (PL) 2025-07-30 EP disclosed
US-4302238-A Herbicidal isoxazolidine-3,5-diones FMC CORPORATION (US) 1981-11-24 US disclosed
US-4302238-A Herbicidal isoxazolidine-3,5-diones FMC CORPORATION (US) 1981-11-24 US disclosed
US-4256819-A MEROCYANINES EASTMAN KODAK COMPANY (US) 1981-03-17 US disclosed