Sugi Predict

Sugi Predict / Compounds / SCHEMBL3777356

SCHEMBL3777356

SCHEMBL3777356

Fc1ccc(CCn2ncc3c[c]ccc32)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 1/20 0.39
▸ HTR2A P28223 2/20 0.36
▸ HTR2C P28335 2/20 0.36
▸ MGAT2 Q10469 1/20 0.35
▸ PKM P14618 2/20 0.35
▸ MITF O75030 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ GRM2 Q14416 1/20 0.34
▸ MAOA P21397 1/20 0.33
▸ MCHR1 Q99705 1/20 0.33
▸ BRD4 O60885 1/20 0.33
▸ CYP19A1 P11511 1/20 0.33
▸ KMO O15229 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL698497 0.87 RECQL (0.46) CYP1A2HTR2AHTR2CPKMMITF
SCHEMBL27243721 0.79 CYP1A2 (0.45) CYP1A2HTR2AHTR2CKMORECQL
SCHEMBL25396438 0.76 HTR2A (0.42) CYP1A2HTR2AHTR2CKMORECQL
SCHEMBL694562 0.75 RECQL (0.46) CYP1A2HTR2AHTR2CPKMMITF
SCHEMBL3483616 0.75 CYP1A2 (0.45) CYP1A2HTR2AHTR2CKMORECQL
SCHEMBL3482763 0.75 CYP1A2 (0.45) CYP1A2HTR2AHTR2CKMORECQL
SCHEMBL15516548 0.74 CYP1A2 (0.69) CYP1A2HTR2AHTR2CKMORECQL
SCHEMBL2251593 0.74 GRIN1 (0.46) PKMHTTGRM2RECQL
SCHEMBL3483368 0.73 CYP1A2 (0.42) CYP1A2HTR2AHTR2CHTTKMO
SCHEMBL16617402 0.73 CYP1A2 (0.42) CYP1A2HTR2AHTR2CKMORECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8741887-B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors JANSSEN PHARMACEUTICA, NV (BE) 2014-06-03 — — US claimed
US-20130123232-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (US) 2013-05-16 — — US claimed
US-8367653-B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2013-02-05 — — US claimed
US-20100324013-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-12-23 — — US claimed
US-8741887-B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors JANSSEN PHARMACEUTICA, NV (BE) 2014-06-03 — — US disclosed
US-20130123232-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (US) 2013-05-16 — — US disclosed
US-8367653-B2 Azetidinyl diamides as monoacylglycerol lipase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2013-02-05 — — US disclosed
US-20100324013-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-12-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100324013-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS PNLIP, LPL, LIPA CYP1A2 544/4885HTR2A 942/4885HTR2C 2002/4885
US-20130123232-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS PNLIP, LPL, LIPA CYP1A2 544/4885HTR2A 942/4885HTR2C 2002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.