Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.75 |
| ▸ | PRKCA | P17252 | 13/20 | 0.75 |
| ▸ | PRKCB | P05771 | 12/20 | 0.75 |
| ▸ | PRKCG | P05129 | 10/20 | 0.75 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.75 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.75 |
| ▸ | PRKACA | P17612 | 3/20 | 0.55 |
| ▸ | PRKACG | P22612 | 3/20 | 0.55 |
| ▸ | PRKACB | P22694 | 3/20 | 0.55 |
| ▸ | PIM1 | P11309 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | PRKCH | P24723 | 3/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13013272 | 0.86 | GSK3B (1.00) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL5754176 | 0.85 | PRKCA (0.75) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL5755677 | 0.84 | PRKCA (0.80) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL5756314 | 0.84 | PRKCA (0.73) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL5757698 | 0.83 | PRKCA (0.73) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL5752512 | 0.83 | PRKCA (0.67) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL3780989 | 0.83 | PRKCA (0.72) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL3775416 | 0.82 | GSK3B (0.79) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL5755061 | 0.82 | PRKCA (0.67) | GSK3BPRKCAPRKCBPRKCGPRKCD | |
| SCHEMBL3784374 | 0.81 | PRKCA (0.76) | GSK3BPRKCAPRKCBPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855203-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855203-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7329657-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329657-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7304060-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304060-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |
| US-20050004202-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ZHANG HAN-CHENG (US) | 2005-01-06 | — | — | US | disclosed |
| US-20040259928-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ZHANG HAN-CHENG (US) | 2004-12-23 | — | — | US | disclosed |
| EP-1362047-A2 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-11-19 | — | — | EP | disclosed |
| US-20030055097-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-03-20 | — | — | US | disclosed |
| WO-2002046183-A2 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP2K3 | GSK3B 601/4885PRKCA 43/4885PRKCB 40/4885 |
| US-20040259928-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP3K1 | GSK3B 587/4885PRKCA 53/4885PRKCB 51/4885 |
| US-20030055097-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP3K1 | GSK3B 587/4885PRKCA 53/4885PRKCB 51/4885 |
| US-20050004202-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP2K3 | GSK3B 601/4885PRKCA 43/4885PRKCB 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.