Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 15/20 | 0.75 |
| ▸ | PRKCB | P05771 | 14/20 | 0.75 |
| ▸ | GSK3B | P49841 | 11/20 | 0.75 |
| ▸ | PRKCG | P05129 | 10/20 | 0.75 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.69 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.69 |
| ▸ | PRKACA | P17612 | 3/20 | 0.64 |
| ▸ | PRKACG | P22612 | 3/20 | 0.64 |
| ▸ | PRKACB | P22694 | 3/20 | 0.64 |
| ▸ | PIM1 | P11309 | 2/20 | 0.64 |
| ▸ | PRKCH | P24723 | 3/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.59 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3768464 | 0.92 | PRKCA (0.65) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3779533 | 0.91 | PRKCA (0.64) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3770811 | 0.91 | PRKCA (0.66) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5756314 | 0.91 | PRKCA (0.73) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5755677 | 0.91 | PRKCA (0.80) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5756125 | 0.90 | PRKD1 (0.63) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3775416 | 0.89 | GSK3B (0.79) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3775940 | 0.89 | PRKCA (0.61) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3768487 | 0.89 | PRKCA (0.65) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3784374 | 0.88 | PRKCA (0.76) | PRKCAPRKCBGSK3BPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |