Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928351 | 1.00 | SIGMAR1 (0.50) | SIGMAR1FUCA1DRD2DRD3ACHE | |
| SCHEMBL3784554 | 1.00 | SIGMAR1 (0.50) | SIGMAR1FUCA1DRD2DRD3ACHE | |
| SCHEMBL12620778 | 0.92 | SIGMAR1 (0.59) | SIGMAR1FUCA1DRD2DRD3ACHE | |
| SCHEMBL12620702 | 0.91 | SIGMAR1 (0.47) | SIGMAR1FUCA1DRD2DRD3ACHE | |
| SCHEMBL10153141 | 0.89 | ACHE (0.51) | SIGMAR1DRD2DRD3ACHEBCHE | |
| SCHEMBL653224 | 0.88 | FUCA1 (0.55) | SIGMAR1FUCA1DRD2DRD3GRIN2B | |
| SCHEMBL477142 | 0.88 | FUCA1 (0.55) | SIGMAR1FUCA1DRD2DRD3GRIN2B | |
| Hydrochloric Acid SCHEMBL2264027 | 0.86 | FUCA1 (0.53) | SIGMAR1FUCA1DRD2DRD3GRIN2B | |
| Hydrochloric Acid SCHEMBL3018917 | 0.86 | FUCA1 (0.53) | SIGMAR1FUCA1DRD2DRD3GRIN2B | |
| SCHEMBL12181407 | 0.83 | ACHE (0.44) | SIGMAR1FUCA1DRD2DRD3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | SIGMAR1 227/4885FUCA1 4045/4885DRD2 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.