Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.58 |
| ▸ | HTR1D | P28221 | 12/20 | 0.58 |
| ▸ | HTR1B | P28222 | 12/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12346145 | 0.88 | HTR1A (0.67) | HTR1ASLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL5217424 | 0.87 | DRD4 (0.69) | HTR1AHTR1DDRD2HTR2APARP1 | |
| Hydrochloric Acid SCHEMBL5217446 | 0.86 | DRD4 (0.67) | HTR1AHTR1DDRD2HTR2APARP1 | |
| SCHEMBL12348064 | 0.83 | HTR1A (0.60) | HTR1ASLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL11002313 | 0.82 | PARP1 (0.77) | HTR1ASLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL5658401 | 0.82 | HTR1A (0.58) | HTR1ASLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL531878 | 0.81 | HTR1A (0.65) | HTR1ASLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL532718 | 0.81 | PARP1 (0.80) | HTR1ASLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL14510673 | 0.81 | HTR1A (0.62) | HTR1ASLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL2302865 | 0.80 | HTR1A (0.67) | HTR1ASLC6A4HTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2354139-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | Vertex Pharmaceuticals Incorporated (US) | 2011-08-10 | — | — | EP | disclosed |
| US-20100324030-A1 | 5-Quinoline derivatives having an anti-bacterial activity | MORPHOCHEM AKTIENGESELLSCHAFT FUR KOMBINATORISCHE CHEMIE (DE) | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324030-A1 | 5-Quinoline derivatives having an anti-bacterial activity | TOP2A, TOP1, TOP2B | HTR1A 2919/4885SLC6A4 3191/4885HTR1D 3407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.