Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.39 |
| ▸ | MTOR | P42345 | 4/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701571 | 0.91 | HRH4 (0.44) | PTGS2KMT2APTGS1TLR9TLR7 | |
| SCHEMBL3779078 | 0.90 | MTOR (0.42) | GHSRPIK3CAPTGS2MTORPIK3R1 | |
| SCHEMBL3702614 | 0.89 | HTT (0.42) | PIK3CAMTORMEN1ALDH1A1KMT2A | |
| SCHEMBL3780612 | 0.89 | GHSR (0.39) | GHSRPIK3CAPTGS2MTORMEN1 | |
| SCHEMBL3779641 | 0.85 | HTT (0.50) | PIK3CAMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL3791449 | 0.81 | PDE10A (0.49) | PIK3CAMTORMEN1ALDH1A1KMT2A | |
| SCHEMBL3707756 | 0.81 | HRH4 (0.47) | PTGS2TLR9TLR7 | |
| SCHEMBL13286093 | 0.81 | TLR9 (0.44) | PIK3CAMTORTLR9TLR7PIK3CG | |
| SCHEMBL3781010 | 0.80 | HRH4 (0.52) | ALDH1A1TLR9TLR7 | |
| SCHEMBL3709878 | 0.80 | HRH4 (0.43) | PTGS2PTGS1TLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |