Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12961073 | 0.82 | IDO1 (0.40) | MAPTIDO1GRIN1GRIN2BPOLB | |
| SCHEMBL1051364 | 0.82 | IDO1 (0.40) | MAPTIDO1GRIN1GRIN2BPOLB | |
| SCHEMBL1051365 | 0.82 | IDO1 (0.40) | MAPTIDO1GRIN1GRIN2BPOLB | |
| SCHEMBL11297037 | 0.80 | KDM4E (0.41) | MAPTIDO1GRIN1GRIN2BPOLB | |
| SCHEMBL3705615 | 0.70 | GRIN1 (0.42) | MAPTGRIN1GRIN2BKMT2AALDH1A1 | |
| SCHEMBL1050226 | 0.70 | CTSK (0.43) | MAPTGRIN1GRIN2BKMT2AALDH1A1 | |
| SCHEMBL3705617 | 0.70 | GRIN1 (0.42) | MAPTGRIN1GRIN2BKMT2AALDH1A1 | |
| SCHEMBL1050227 | 0.70 | CTSK (0.43) | MAPTGRIN1GRIN2BKMT2AALDH1A1 | |
| SCHEMBL11297039 | 0.69 | RGS4 (0.44) | MAPTKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL11297038 | 0.69 | GRIN1 (0.42) | MAPTGRIN1GRIN2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451794-A2 | 1,2,4-THIAZOLIDIN-3-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | BALTIC BIO AB (SE) | 2012-05-16 | — | — | EP | disclosed |