Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 14/20 | 0.64 |
| ▸ | PRKCB | P05771 | 13/20 | 0.64 |
| ▸ | GSK3B | P49841 | 11/20 | 0.64 |
| ▸ | PRKCG | P05129 | 10/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.61 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.61 |
| ▸ | PRKACA | P17612 | 3/20 | 0.54 |
| ▸ | PRKACG | P22612 | 3/20 | 0.54 |
| ▸ | PRKACB | P22694 | 3/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.53 |
| ▸ | PRKCH | P24723 | 3/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3770811 | 0.93 | PRKCA (0.66) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5754176 | 0.91 | PRKCA (0.75) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3768464 | 0.91 | PRKCA (0.65) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5757844 | 0.91 | GSK3B (0.67) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5756125 | 0.89 | PRKD1 (0.63) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3775940 | 0.88 | PRKCA (0.61) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3771437 | 0.88 | PRKCA (0.84) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5758690 | 0.88 | PRKCA (0.63) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3771589 | 0.87 | PRKCA (0.84) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3768487 | 0.86 | PRKCA (0.65) | PRKCAPRKCBGSK3BPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855203-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855203-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7329657-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329657-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7304060-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304060-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-20050004202-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ZHANG HAN-CHENG (US) | 2005-01-06 | — | — | US | disclosed |
| US-20040259928-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ZHANG HAN-CHENG (US) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096949-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP2K3 | PRKCA 43/4885PRKCB 40/4885GSK3B 601/4885 |
| US-20040259928-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP3K1 | PRKCA 53/4885PRKCB 51/4885GSK3B 587/4885 |
| US-20050004202-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP2K3 | PRKCA 43/4885PRKCB 40/4885GSK3B 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.