Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786017 | 0.89 | MAPT (0.51) | KMT2AMAPTMEN1SMN1; SMN2LMNA | |
| SCHEMBL3787718 | 0.87 | MEN1 (0.46) | KMT2AMAPTMEN1LMNAGAA | |
| SCHEMBL13286377 | 0.81 | CNR2 (0.51) | CNR2KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL3783305 | 0.81 | MEN1 (0.49) | KMT2AMAPTMEN1SMN1; SMN2LMNA | |
| SCHEMBL3780333 | 0.80 | CNR2 (0.48) | CNR2KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL3781754 | 0.78 | PTGS2 (0.46) | KMT2AMAPTMEN1LMNAGAA | |
| SCHEMBL3782842 | 0.77 | ALDH1A1 (0.51) | KMT2AMEN1LMNAHPGDMAPK1 | |
| SCHEMBL13286144 | 0.77 | PTGS2 (0.47) | — | |
| SCHEMBL3785011 | 0.77 | PTGS2 (0.45) | KMT2AMAPTMEN1LMNAGAA | |
| Ammonia Solution, Strong SCHEMBL3787729 | 0.75 | MAPT (0.46) | CNR2KMT2AMAPTMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |