⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13685915 | 0.78 | — | — | |
| SCHEMBL13055305 | 0.77 | CA12 (0.40) | — | |
| SCHEMBL20377309 | 0.76 | CA12 (0.37) | — | |
| SCHEMBL14000571 | 0.75 | CA12 (0.39) | — | |
| SCHEMBL14000536 | 0.75 | CA12 (0.39) | — | |
| SCHEMBL28321395 | 0.72 | — | — | |
| SCHEMBL2079547 | 0.71 | GLA (0.58) | — | |
| SCHEMBL8936076 | 0.71 | GLA (0.44) | — | |
| SCHEMBL8936017 | 0.71 | CATSPER1 (0.39) | — | |
| SCHEMBL9213055 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10456405-B2 | Nitric oxide-releasing prodrug molecule of substituted quinazolines | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) | 2019-10-29 | — | — | US | disclosed |
| CN-106032378-B | New A RB compound and application thereof | 武汉启瑞药业有限公司 | 2019-10-25 | — | — | CN | disclosed |
| US-20180250305-A1 | NITRIC OXIDE-RELEASING PRODRUG MOLECULE | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2018-09-06 | — | — | US | disclosed |
| EP-3348548-A1 | NITRIC OXIDE-RELEASING PRODRUG MOLECULE | Zhejiang Huahai Pharmaceutical Co., Ltd (CN) | 2018-07-18 | — | — | EP | disclosed |
| US-9708306-B2 | Benzimidazole derivatives and preparation process and pharmaceutical uses thereof | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD (CN) | 2017-07-18 | — | — | US | disclosed |
| US-20170172970-A1 | VECTOR DELIVERY-BASED MICROBICIDES | RUSH UNIVERSITY MEDICAL CENTER (US) | 2017-06-22 | — | — | US | disclosed |
| US-20170172970-A1 | VECTOR DELIVERY-BASED MICROBICIDES | RUSH UNIVERSITY MEDICAL CENTER (US) | 2017-06-22 | — | — | US | disclosed |
| US-9603841-B2 | Vector delivery-based microbicides | RUSH UNIVERSITY MEDICAL CENTER (US) | 2017-03-28 | — | — | US | disclosed |
| US-9603841-B2 | Vector delivery-based microbicides | RUSH UNIVERSITY MEDICAL CENTER (US) | 2017-03-28 | — | — | US | disclosed |
| US-20170022188-A1 | Benzimidazole Derivatives and Preparation Process and Pharmaceutical Uses Thereof | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2017-01-26 | — | — | US | disclosed |
| US-9233101-B2 | — | — | 2016-01-12 | — | — | US | disclosed |
| US-9233101-B2 | — | — | 2016-01-12 | — | — | US | disclosed |
| US-20100331404-A1 | Vector Delivery-Based Microbicides | RUSH UNIVERSITY MEDICAL CENTER (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331404-A1 | Vector Delivery-Based Microbicides | RUSH UNIVERSITY MEDICAL CENTER (US) | 2010-12-30 | — | — | US | disclosed |
| US-7595313-B2 | Nitric oxide donating diuretic compounds, compositions and methods of use | NICOX, S.A. (FR) | 2009-09-29 | — | — | US | disclosed |
| US-20080287407-A1 | Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use | NITROMED, INC. (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080255101-A1 | NITRIC OXIDE DONATING DIURETIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| US-7396829-B2 | such as 2H-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[5-(nitrooxy)pentyl]-, 1,1-dioxide; contains at least one nitric oxide enhancing group; excessive water or electrolyte retention conditions; cardiovascular diseases, and diseases resulting from oxidative or endothelial dysfunctions | NITROMED, INC. (US) | 2008-07-08 | — | — | US | disclosed |
| WO-2007022082-A2 | VECTOR DELIVERY-BASED MICROBICIDES | RUSH UNIVERSITY MEDICAL CENTER (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2007022082-A2 | VECTOR DELIVERY-BASED MICROBICIDES | RUSH UNIVERSITY MEDICAL CENTER (US) | 2007-02-22 | — | — | WO | disclosed |