Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 8/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.34 |
| ▸ | GRK5 | P34947 | 10/20 | 0.34 |
| ▸ | GRK2 | P25098 | 6/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786133 | 0.90 | LRRK2 (0.36) | LRRK2METKCNH2ILKMAP4K3 | |
| SCHEMBL3789591 | 0.89 | LRRK2 (0.41) | LRRK2ILKMAP4K3TGFBR1ACVR1 | |
| SCHEMBL3790471 | 0.87 | MAP4K3 (0.35) | LRRK2METKCNH2ILKMAP4K3 | |
| SCHEMBL3787024 | 0.87 | LRRK2 (0.37) | LRRK2METKCNH2ILKMAP4K3 | |
| SCHEMBL3792486 | 0.86 | LRRK2 (0.36) | LRRK2METKCNH2ILKMAP4K3 | |
| Hydrochloric Acid SCHEMBL3785299 | 0.85 | LRRK2 (0.35) | LRRK2METKCNH2ILKMAP4K3 | |
| Hydrochloric Acid SCHEMBL3786770 | 0.85 | ILK (0.50) | METKCNH2ILK | |
| SCHEMBL3791132 | 0.80 | ILK (0.41) | LRRK2METILKMAP4K3GRK5 | |
| SCHEMBL3791085 | 0.80 | ILK (0.44) | METILKGRK5GRK2 | |
| SCHEMBL3790558 | 0.80 | MAPT (0.43) | LRRK2METILKMAP4K3GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |