Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | MET | P08581 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MAP4K3 | Q8IVH8 | 6/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3781328 | 0.90 | LRRK2 (0.38) | LRRK2ILKMETKCNH2MAP4K3 | |
| SCHEMBL3789591 | 0.89 | LRRK2 (0.41) | LRRK2ILKJAK2MAP4K3ALK | |
| SCHEMBL3790471 | 0.87 | MAP4K3 (0.35) | LRRK2ILKMETKCNH2MAP4K3 | |
| SCHEMBL3787024 | 0.87 | LRRK2 (0.37) | LRRK2ILKMETKCNH2MAP4K3 | |
| SCHEMBL3791691 | 0.86 | LRRK2 (0.36) | LRRK2ILKJAK2METKCNH2 | |
| Hydrochloric Acid SCHEMBL3785299 | 0.85 | LRRK2 (0.35) | LRRK2ILKMETKCNH2MAP4K3 | |
| Hydrochloric Acid SCHEMBL3786770 | 0.85 | ILK (0.50) | ILKMETKCNH2 | |
| SCHEMBL3792929 | 0.83 | NPC1 (0.47) | LRRK2ILKMETMAP4K3ALK | |
| SCHEMBL3788570 | 0.83 | APP (0.41) | LRRK2ILKMETMAP4K3ALK | |
| SCHEMBL3792301 | 0.81 | MAPT (0.43) | LRRK2ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |