Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | GCGR | P47871 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SCN4A | P35499 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015796 | 0.84 | LTA4H (0.51) | LTA4HMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL30312207 | 0.83 | KMT2A (0.44) | LTA4HNPC1RAB9ANISCHCYP2D6 | |
| SCHEMBL27876872 | 0.77 | KDM4E (0.48) | NPC1SCN4ARAB9AKDM4E | |
| SCHEMBL30312010 | 0.75 | KDM4E (0.47) | NPC1SCN4ARAB9AKDM4EUSP2 | |
| SCHEMBL30311895 | 0.72 | ALDH1A1 (0.51) | NPC1RAB9AKDM4ECYP3A4CYP2D6 | |
| SCHEMBL30311988 | 0.72 | SCN5A (0.44) | NPC1RAB9ASCN9ANISCH | |
| SCHEMBL30311926 | 0.71 | SCN5A (0.47) | SCN9ANISCH | |
| SCHEMBL12127665 | 0.70 | LTA4H (0.38) | LTA4HSCN9ACYP2D6HAO1 | |
| SCHEMBL30311943 | 0.70 | CYP2D6 (0.60) | NPC1RAB9AKDM4ECYP3A4CYP2D6 | |
| SCHEMBL21379767 | 0.70 | MAPT (0.61) | LTA4HMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084618-B2 | Heterocyclic compounds and methods of use | TARGEGEN, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100330069-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | TARGEGEN, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100330069-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AADAC, NISCH, PAICS | LTA4H 1864/4885MAPK13 3698/4885MAPK12 3476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.