Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.76 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.76 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.76 |
| ▸ | ENPP1 | P22413 | 6/20 | 0.71 |
| ▸ | NT5E | P21589 | 2/20 | 0.71 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.71 |
| ▸ | PI4KA | P42356 | 1/20 | 0.67 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.67 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.67 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.58 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22392998 | 0.91 | P2RX3 (0.84) | P2RX3P2RX1P2RX4PI4KAPI4K2B | |
| SCHEMBL26361537 | 0.91 | P2RX3 (0.84) | P2RX3P2RX1P2RX4PI4KAPI4K2B | |
| SCHEMBL22402648 | 0.91 | P2RX3 (0.84) | P2RX3P2RX1P2RX4PI4KAPI4K2B | |
| SCHEMBL23922240 | 0.88 | P2RX3 (0.97) | P2RX3P2RX1P2RX4PI4KAPI4K2B | |
| SCHEMBL14414863 | 0.88 | P2RX3 (0.97) | P2RX3P2RX1P2RX4PI4KAPI4K2B | |
| SCHEMBL24145102 | 0.86 | P2RX3 (0.87) | P2RX3P2RX1P2RX4PI4KAPI4K2B | |
| SCHEMBL27480257 | 0.86 | PI4KA (0.76) | P2RX3P2RX1P2RX4ENPP1NT5E | |
| SCHEMBL16351390 | 0.86 | ENPP1 (0.71) | P2RX3P2RX1P2RX4ENPP1NT5E | |
| SCHEMBL22402624 | 0.84 | P2RX3 (0.70) | P2RX3P2RX1P2RX4ENPP1NT5E | |
| SCHEMBL23922243 | 0.84 | P2RX3 (0.70) | P2RX3P2RX1P2RX4ENPP1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2803357-B1 | Angiogenesis inhibitors | UNIV JOHNS HOPKINS (US) | 2020-11-18 | — | — | EP | disclosed |
| US-9642865-B2 | Angiogenesis inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-20150056267-A1 | ANGIOGENESIS INHIBITORS | UNIV JOHNS HOPKINS (US) | 2015-02-26 | — | — | US | disclosed |
| US-20130101657-A1 | ANGIOGENESIS INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-04-25 | — | — | US | disclosed |
| US-20100330148-A1 | MEHODS AND COMPOSITIONS FOR INHIBITING IMPDH-1 ISOFORM 1 | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2007109363-A2 | METHODS AND COMPOSITIONS FOR INHIBITING IMPDH ISOFORM 1 | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-09-27 | — | — | WO | disclosed |
| EP-1765336-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS-HOPKINS UNIVERSITY (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006004795-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150056267-A1 | ANGIOGENESIS INHIBITORS | FLT1, VEGFA, FLT4 | P2RX3 3585/4885P2RX1 3543/4885P2RX4 3786/4885 |
| US-20100330148-A1 | MEHODS AND COMPOSITIONS FOR INHIBITING IMPDH-1 ISOFORM 1 | IMPDH1, IMPDH2, IMPA1 | P2RX3 2092/4885P2RX1 1318/4885P2RX4 2554/4885 |
| US-20130101657-A1 | ANGIOGENESIS INHIBITORS | FLT1, VEGFA, FLT4 | P2RX3 3585/4885P2RX1 3543/4885P2RX4 3786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.