Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 2/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4125901 | 0.92 | NAMPT (0.35) | NAMPTFEN1SLC40A1ALDH1A1 | |
| SCHEMBL4126978 | 0.91 | NAMPT (0.34) | NAMPTFEN1PTGER2TAS2R14SLC40A1 | |
| SCHEMBL4117657 | 0.90 | GPBAR1 (0.33) | NAMPTGPBAR1 | |
| SCHEMBL4130745 | 0.90 | GPBAR1 (0.40) | NAMPTPTGER2SLC40A1GPBAR1ALDH1A1 | |
| SCHEMBL3649326 | 0.89 | HTR6 (0.39) | ALDH1A1 | |
| SCHEMBL4126631 | 0.88 | ALDH1A1 (0.41) | NAMPTALDH1A1LMNA | |
| SCHEMBL3654891 | 0.87 | ATM (0.34) | NAMPTALDH1A1LMNA | |
| SCHEMBL4132659 | 0.86 | NAMPT (0.39) | NAMPTPTGER2ALDH1A1CA12CA1 | |
| SCHEMBL4125865 | 0.86 | LIMK2 (0.33) | NAMPTALDH1A1HPGDCA12CA1 | |
| SCHEMBL4126584 | 0.86 | NAMPT (0.37) | NAMPTFEN1PTGER2TAS2R14GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |