Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | VCP | P55072 | 7/20 | 0.64 |
| ▸ | PSMC4 | P43686 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 6/20 | 0.54 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | BTK | Q06187 | 3/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | YES1 | P07947 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | FRK | P42685 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13019726 | 0.87 | HTT (0.84) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL3784196 | 0.85 | HTT (0.74) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL3781673 | 0.84 | HTT (1.00) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL13020198 | 0.84 | HTT (0.76) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL3782302 | 0.83 | HTT (0.80) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL5066872 | 0.82 | VCP (0.73) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL13019971 | 0.82 | KDM4E (0.69) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL13019982 | 0.82 | HTT (0.78) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL13020027 | 0.82 | HTT (0.78) | HTTKDM4EALDH1A1VCPPSMC4 | |
| SCHEMBL13020021 | 0.82 | HTT (0.78) | HTTKDM4EALDH1A1VCPPSMC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | RAB1A, COPB1, GOLT1B | HTT 187/4885KDM4E 4425/4885ALDH1A1 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.