Sugi Predict

Sugi Predict / Compounds / SCHEMBL378246

SCHEMBL378246

SCHEMBL378246

Cc1cc(C(F)(F)F)ccc1N

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.52
▸ TSHR P16473 2/20 0.52
▸ CYP3A4 P08684 2/20 0.52
▸ TDP1 Q9NUW8 2/20 0.52
▸ ESR1 P03372 2/20 0.48
▸ AR P10275 1/20 0.48
▸ ESR2 Q92731 1/20 0.48
▸ KDM4E B2RXH2 3/20 0.47
▸ PKM P14618 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ MAPK1 P28482 1/20 0.46
▸ CFTR P13569 1/20 0.46
▸ S100B P04271 1/20 0.45
▸ L3MBTL1 Q9Y468 4/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ NOS3 P29474 1/20 0.43
▸ NOS2 P35228 1/20 0.43
▸ KIF11 P52732 3/20 0.43
▸ MAPT P10636 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6062984 0.98 ALDH1A1 (0.50) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL11689624 0.96 ALDH1A1 (0.48) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL3893690 0.86 ALDH1A1 (0.65) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL330442 0.84 ALDH1A1 (0.50) ALDH1A1TSHRCYP3A4TDP1KDM4E
SCHEMBL13905695 0.84 CYP3A4 (0.50) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL23644120 0.84 CYP3A4 (0.50) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL2718835 0.82 CYP3A4 (0.48) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL29598324 0.82 CYP3A4 (0.48) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL1352918 0.82 CYP3A4 (0.48) ALDH1A1TSHRCYP3A4TDP1ESR1
SCHEMBL3897342 0.82 CYP3A4 (0.48) ALDH1A1TSHRCYP3A4TDP1ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 324 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4363404-A1 A PHARMACEUTICAL PRODUCT CONTAINING TASQUINIMOD AND A METHOD FOR ASSESSING THE PURITY OF SAID PRODUCT Active Biotech AB (SE) 2024-05-08 — — EP claimed
WO-2023275248-A1 A PHARMACEUTICAL PRODUCT CONTAINING TASQUINIMOD AND A METHOD FOR ASSESSING THE PURITY OF SAID PRODUCT ACTIVE BIOTECH AB (SE) 2023-01-05 — — WO claimed
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 — — EP disclosed
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2026-03-05 — — US disclosed
EP-4692088-A1 COMPOUND ACTING AS WRN HELICASE INHIBITOR SHANGHAI JEYOU PHARMACEUTICAL CO., LTD. (CN) 2026-02-11 — — EP disclosed
US-12528828-B2 Substituted pyrido[4,3-d]pyrimidines as KRAS modulators ALTEROME THERAPEUTICS, INC. (US) 2026-01-20 — — US disclosed
US-20250346610-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS ALTEROME THERAPEUTICS INC (US) 2025-11-13 — — US disclosed
US-12466842-B2 Substituted pyrido [4,3-d]pyrimidines as KRAS modulators ALTEROME THERAPEUTICS, INC. (US) 2025-11-11 — — US disclosed
US-20250282799-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS ALTEROME THERAPEUTICS, INC. 2025-09-11 — — US disclosed
EP-4601746-A1 TRICYCLIC COMPOUNDS AND THEIR USES Novartis AG (CH) 2025-08-20 — — EP disclosed
US-20250230168-A1 AZASPIRO WRN INHIBITORS GILEAD SCIENCES, INC. 2025-07-17 — — US disclosed
EP-0023100-B1 HERBICIDAL COMPOSITIONS COMPRISING A DIPHENYL ETHER COMPOUND IN ADMIXTURE WITH ANOTHER HERBICIDE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-10 — — EP disclosed
US-4358591-A BACTERICIDES, FUNGICIDES; PLANT DISEASES ZOECON CORPORATION (US) 1982-11-09 — — US disclosed
US-4338318-A FUNGICIDE OR BACERICIDE TO TREAT PLANT DISEASES WITH A PHENYL URACIL ZOECON CORPORATION (US) 1982-07-06 — — US disclosed
US-4307098-A 2-PHENYL-URACIL COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-12-22 — — US disclosed
US-4297297-A α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates ZOECON CORP. (US) 1981-10-27 — — US disclosed
US-4266056-A FUNGICIDES, BACTERICIDES ZOECON CORPORATION (US) 1981-05-05 — — US disclosed
EP-0023100-A1 Herbicidal compositions comprising a diphenyl ether compound in admixture with another herbicide IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-01-28 — — EP disclosed
US-4132737-A ENZYME INHIBITORS ELI LILLY AND COMPANY (US) 1979-01-02 — — US disclosed
US-4059402-A SUBLIMATION, MONOAZO DYES BAYER AKTIENGESELLSCHAFT (DT) 1977-11-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250230168-A1 AZASPIRO WRN INHIBITORS WRN, RECQL, BLM ALDH1A1 1316/4885TSHR 3555/4885CYP3A4 3769/4885
US-20250346610-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS KRAS, NRAS, HRAS ALDH1A1 3593/4885TSHR 3993/4885CYP3A4 3084/4885
US-12466842-B2 Substituted pyrido [4,3-d]pyrimidines as KRAS modulators KRAS, NRAS, HRAS ALDH1A1 3593/4885TSHR 3993/4885CYP3A4 3084/4885
US-20250282799-A1 SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS KRAS, NRAS, HRAS ALDH1A1 3593/4885TSHR 3993/4885CYP3A4 3084/4885
US-12528828-B2 Substituted pyrido[4,3-d]pyrimidines as KRAS modulators KRAS, NRAS, HRAS ALDH1A1 1854/4885TSHR 263/4885CYP3A4 3003/4885
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF KRAS, NRAS, HRAS ALDH1A1 908/4885TSHR 2091/4885CYP3A4 1005/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.