Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9884989 | 0.83 | BCDIN3D (0.54) | KDM4EPKMBCDIN3DPRMT5BRD4 | |
| SCHEMBL620090 | 0.83 | KDM4E (0.50) | KDM4EPKMBCDIN3DPRMT5BRD4 | |
| SCHEMBL3779057 | 0.83 | KDM4E (0.53) | KDM4EPKMBCDIN3DPRMT5CCNT1 | |
| SCHEMBL3784091 | 0.80 | ALDH1A1 (0.45) | BRD4HSP90AA1HSP90AB1MAPT | |
| SCHEMBL3784088 | 0.80 | ALDH1A1 (0.45) | BRD4HSP90AA1HSP90AB1MAPT | |
| SCHEMBL5403405 | 0.80 | KDM4E (0.54) | KDM4EPKMBCDIN3DPRMT5BRD4 | |
| SCHEMBL15757759 | 0.80 | KDM4E (0.48) | KDM4EPKMBCDIN3DPRMT5BRD4 | |
| SCHEMBL31637303 | 0.79 | BCDIN3D (0.49) | KDM4EPKMBCDIN3DBRD4IDO1 | |
| SCHEMBL4646351 | 0.79 | KDM4E (0.53) | KDM4EPKMBCDIN3DPRMT5BRD4 | |
| SCHEMBL29492796 | 0.78 | IDO1 (0.49) | KDM4EPKMBCDIN3DBRD4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | KDM4E 2061/4885PKM 2598/4885BCDIN3D 2074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.