Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585898 | 0.90 | GPR119 (0.48) | KDM4EPKMGPR119 | |
| SCHEMBL23558620 | 0.86 | NAMPT (0.53) | KDM4EPKMPRMT5KDM1AGPR119 | |
| SCHEMBL29501504 | 0.85 | NR1H2 (0.51) | KDM4EPKMPRMT5BRD4CCNT1 | |
| SCHEMBL23545080 | 0.85 | NR1H2 (0.51) | KDM4EPKMPRMT5BRD4CCNT1 | |
| SCHEMBL20936864 | 0.85 | NR1H2 (0.51) | KDM4EPKMPRMT5BRD4CCNT1 | |
| SCHEMBL22797037 | 0.84 | PTPN2 (0.62) | STSMAPTNPC1ALDH1A1MAPK1 | |
| SCHEMBL6586005 | 0.83 | KDM4E (0.53) | KDM4EPKMBRD4KDM1ATGFBR1 | |
| SCHEMBL22797244 | 0.83 | ALDH1A1 (0.58) | PRMT5BRD4CCNT1GPR119JAK1 | |
| SCHEMBL16043728 | 0.83 | KDM4E (0.52) | KDM4EPKMPRMT5BRD4CCNT1 | |
| SCHEMBL20641623 | 0.82 | NAMPT (0.53) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294627-B2 | Chemical compounds | ELI LILLY AND COMPANY (US) | 2007-11-13 | — | — | US | disclosed |
| US-20040249151-A1 | Factor Xa inhibitors, useful in therapy of thrombotic disorders | ELI LILLY AND COMPANY | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040249151-A1 | Factor Xa inhibitors, useful in therapy of thrombotic disorders | F11, SERPINC1, F2 | KDM4E 3477/4885PKM 4228/4885PRMT5 1204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.