Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771864 | 0.88 | PIK3CD (0.47) | DHODHGAAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3784614 | 0.87 | PIK3CD (0.44) | DHODHGAAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2717982 | 0.83 | DHODH (0.49) | DHODHGAAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15226592 | 0.77 | PIK3CD (0.58) | GAAPIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL3777054 | 0.77 | PIK3CD (0.42) | DHODHGAAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3782641 | 0.76 | PIK3CD (0.43) | DHODHGAAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL13063146 | 0.75 | PIK3CD (0.46) | DHODHGAAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2720732 | 0.75 | PIK3CD (0.81) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2717791 | 0.75 | PIK3CD (0.41) | DHODHGAAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2719948 | 0.75 | ALDH1A1 (0.47) | DHODHGAAMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873704-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20160333017-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2016-11-17 | — | — | US | disclosed |
| EP-2445900-B1 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | AMGEN INC (US) | 2016-03-02 | — | — | EP | disclosed |
| US-20100331306-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331306-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | DHODH 3116/4885GAA 2646/4885PIK3CD 15/4885 |
| US-20160333017-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | DHODH 3134/4885GAA 2664/4885PIK3CD 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.