Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 9/20 | 0.46 |
| ▸ | PRNP | P04156 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718169 | 0.86 | ALDH1A1 (0.45) | ALDH1A1DHODHPRNPTDP1PLA2G2A | |
| SCHEMBL2717623 | 0.86 | CKS1B (0.41) | ALDH1A1DHODHPRNPTDP1PLA2G2A | |
| SCHEMBL2717984 | 0.82 | DHODH (0.50) | ALDH1A1DHODHPRNPTDP1POLB | |
| SCHEMBL6122794 | 0.78 | ALDH1A1 (0.47) | ALDH1A1DHODHPLA2G2AMAPTMEN1 | |
| SCHEMBL2719964 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TDP1PLA2G2APOLBMAPT | |
| SCHEMBL2717553 | 0.76 | IDO1 (0.40) | ALDH1A1DHODHPRNPPLA2G2APOLB | |
| SCHEMBL2719179 | 0.75 | GNRHR (0.42) | ALDH1A1DHODHPRNPMTNR1AMTNR1B | |
| SCHEMBL3784083 | 0.75 | DHODH (0.47) | ALDH1A1DHODHPRNPTDP1PLA2G2A | |
| SCHEMBL2717125 | 0.74 | PIK3CD (0.57) | — | |
| SCHEMBL2717794 | 0.74 | GNRHR (0.41) | ALDH1A1DHODHPRNPPLA2G2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |