Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.51 |
| ▸ | PRKDC | P78527 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 5/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13020102 | 0.86 | EGFR (0.47) | PIK3CDPRKDCKDRRETFYN | |
| SCHEMBL13063879 | 0.80 | SRC (0.61) | PIK3CDPRKDCKDRRETFYN | |
| SCHEMBL15826968 | 0.76 | PIK3CD (0.73) | PIK3CDPRKDCKDRRETFYN | |
| SCHEMBL13020099 | 0.76 | BTK (0.52) | PIK3CDPRKDCKDRRETEGFR | |
| SCHEMBL3787263 | 0.73 | PIK3CD (0.52) | PIK3CDPRKDCKDRRETFYN | |
| SCHEMBL13064034 | 0.73 | PIK3CD (0.55) | PIK3CDPRKDCKDRRETFYN | |
| SCHEMBL10261498 | 0.73 | PIK3CD (0.53) | PIK3CDPRKDCKDRRETFYN | |
| SCHEMBL15826969 | 0.70 | PIK3CD (0.51) | PIK3CDPRKDCKDRRETEGFR | |
| SCHEMBL868744 | 0.70 | PIK3CD (0.51) | PIK3CDPRKDCKDRRETFYN | |
| SCHEMBL27943334 | 0.70 | LRRK2 (0.43) | PIK3CDPRKDCKDRRETFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | RAB1A, COPB1, GOLT1B | PIK3CD 2217/4885PRKDC 1498/4885KDR 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.