Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 14/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19281134 | 0.88 | TRPM8 (0.47) | TRPM8TRPV1SPRHDAC3HDAC4 | |
| SCHEMBL537650 | 0.81 | TRPM8 (0.64) | TRPM8TRPV1HDAC3HDAC4HDAC1 | |
| SCHEMBL19281129 | 0.79 | HDAC3 (0.45) | TRPM8TRPV1HDAC3HDAC4HDAC1 | |
| SCHEMBL3794509 | 0.76 | HSD11B1 (0.47) | TRPM8NPC1HDAC3HDAC4HDAC1 | |
| SCHEMBL617187 | 0.72 | TRPM8 (0.36) | TRPM8TRPV1 | |
| SCHEMBL20270684 | 0.71 | IDO1 (0.43) | TRPM8TRPV1 | |
| SCHEMBL11480145 | 0.71 | TRPM8 (0.35) | TRPM8TRPV1 | |
| SCHEMBL12482018 | 0.70 | SCD (0.49) | TRPM8TRPV1HDAC3HDAC4HDAC1 | |
| SCHEMBL18145048 | 0.69 | HDAC3 (0.47) | TRPM8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16496523 | 0.69 | TRPM8 (0.46) | TRPM8TRPV1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103381-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES AS TRPM 8 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-16 | — | — | WO | disclosed |