Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | JUND | P17535 | 1/20 | 0.40 |
| ▸ | FOSB | P53539 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | ILK | Q13418 | 1/20 | 0.35 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786618 | 0.90 | LRRK2 (0.38) | LRRK2ALKFYNTGFBR1ACVR1 | |
| SCHEMBL3787794 | 0.88 | ILK (0.40) | LRRK2ALKILKMAP4K3 | |
| SCHEMBL3792486 | 0.88 | LRRK2 (0.36) | LRRK2ALKTGFBR1ACVR1ILK | |
| SCHEMBL3791691 | 0.88 | LRRK2 (0.36) | LRRK2TDP1ALKF2RL3TGFBR1 | |
| SCHEMBL3790635 | 0.87 | LRRK2 (0.37) | LRRK2ALKILKMAP4K3 | |
| SCHEMBL3789591 | 0.87 | LRRK2 (0.41) | LRRK2JUNDFOSBALKF2RL3 | |
| SCHEMBL3790865 | 0.86 | LRRK2 (0.37) | LRRK2ILKMAP4K3 | |
| Hydrochloric Acid SCHEMBL3786770 | 0.83 | ILK (0.50) | TDP1ILKKDM4EMEN1GAA | |
| SCHEMBL3786015 | 0.82 | DYRK1A (0.49) | LRRK2TGFBR1ILK | |
| SCHEMBL3785286 | 0.82 | APP (0.46) | LRRK2ILKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |