Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 7/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912950 | 0.90 | SYK (0.55) | SYKLCKSTAT6JAK2JAK1 | |
| SCHEMBL19772878 | 0.84 | SYK (0.58) | SYKLCKSTAT6JAK2JAK1 | |
| SCHEMBL737077 | 0.82 | SYK (0.78) | SYK | |
| SCHEMBL913485 | 0.78 | SYK (0.69) | SYKJAK2JAK1JAK3 | |
| SCHEMBL913990 | 0.78 | SYK (0.66) | SYKJAK2JAK1JAK3 | |
| SCHEMBL3792397 | 0.77 | MAPK8 (0.49) | SYKSTAT6 | |
| SCHEMBL14982156 | 0.77 | SYK (0.55) | SYKSTAT6JAK2JAK1JAK3 | |
| SCHEMBL3712976 | 0.77 | SYK (0.52) | SYKSTAT6JAK2JAK1JAK3 | |
| SCHEMBL913830 | 0.76 | SYK (0.58) | SYKJAK2JAK1JAK3 | |
| SCHEMBL3793017 | 0.74 | SYK (0.49) | SYKSTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |