Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 4/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914208 | 0.87 | SYK (0.51) | SYKSTAT6 | |
| SCHEMBL3792397 | 0.86 | MAPK8 (0.49) | SYKMAPK8STAT6 | |
| SCHEMBL3790334 | 0.82 | JAK3 (0.60) | SYKSTAT6 | |
| SCHEMBL914007 | 0.79 | STAT6 (0.57) | SYKSTAT6 | |
| SCHEMBL3793275 | 0.76 | SYK (0.59) | SYK | |
| SCHEMBL3800518 | 0.75 | SYK (0.58) | SYK | |
| SCHEMBL3786482 | 0.75 | SYK (0.61) | SYK | |
| SCHEMBL3786154 | 0.74 | SYK (0.52) | SYKSTAT6 | |
| SCHEMBL914015 | 0.74 | STAT6 (0.59) | SYKMAPK8STAT6 | |
| SCHEMBL3791847 | 0.73 | SYK (0.63) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |