Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535810 | 0.82 | TSHR (0.58) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL3789593 | 0.79 | CA1 (0.60) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL9575753 | 0.78 | TSHR (0.52) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL8904530 | 0.76 | CA1 (0.51) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL828589 | 0.76 | CA1 (0.51) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL4537628 | 0.76 | CA1 (0.51) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL17770696 | 0.76 | TSHR (0.50) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL14814507 | 0.76 | TSHR (0.50) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL10581265 | 0.75 | TSHR (0.48) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL9845277 | 0.75 | TSHR (0.48) | TSHRCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |