Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 4/20 | 0.37 |
| ▸ | GRK2 | P25098 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3792500 | 0.96 | CASP3 (0.39) | L3MBTL1GRK5GRK2LRRK2JAK2 | |
| SCHEMBL3790505 | 0.90 | LRRK2 (0.36) | GRK5GRK2LRRK2METFGFR1 | |
| Hydrochloric Acid SCHEMBL3790288 | 0.89 | MET (0.38) | GRK5GRK2LRRK2JAK2MET | |
| Hydrochloric Acid SCHEMBL3791572 | 0.89 | LRRK2 (0.36) | GRK5GRK2LRRK2ABL1MET | |
| Hydrochloric Acid SCHEMBL3788088 | 0.88 | LRRK2 (0.40) | GRK5GRK2LRRK2METFGFR1 | |
| Hydrochloric Acid SCHEMBL3784591 | 0.88 | MAP4K3 (0.37) | GRK5GRK2LRRK2MAP4K3ALOX5AP | |
| Hydrochloric Acid SCHEMBL3792299 | 0.88 | LRRK2 (0.45) | GRK5GRK2LRRK2CASP3SENP7 | |
| Hydrochloric Acid SCHEMBL3791784 | 0.87 | TYRO3 (0.38) | GRK5GRK2LRRK2FGFR1FGFR2 | |
| Hydrochloric Acid SCHEMBL3786764 | 0.87 | LRRK2 (0.40) | GRK5GRK2LRRK2METMKNK1 | |
| Hydrochloric Acid SCHEMBL3787602 | 0.87 | SLC6A2 (0.39) | GRK5GRK2LRRK2FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |