Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786840 | 0.89 | KDM4E (0.48) | KDM4EL3MBTL1MAPK1TDP1CCR6 | |
| SCHEMBL3788064 | 0.89 | MAPT (0.50) | KDM4EL3MBTL1MAPK1TDP1CCR6 | |
| SCHEMBL3794726 | 0.80 | SGK1 (0.48) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31531878 | 0.78 | KDM4E (0.79) | KDM4EL3MBTL1MAPK1TDP1CCR6 | |
| SCHEMBL12118854 | 0.78 | ALDH1A1 (0.51) | KDM4EL3MBTL1CCR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL29904820 | 0.78 | ALDH1A1 (0.51) | KDM4EL3MBTL1CCR6ALDH1A1SMN1; SMN2 | |
| SCHEMBL12118859 | 0.78 | ALDH1A1 (0.51) | KDM4EL3MBTL1MAPK1ALDH1A1HPGD | |
| SCHEMBL10678483 | 0.78 | KDM4E (0.79) | KDM4EL3MBTL1MAPK1TDP1CCR6 | |
| SCHEMBL14894867 | 0.77 | PLA2G2A (0.49) | KDM4EL3MBTL1MAPK1TDP1ALDH1A1 | |
| SCHEMBL29904837 | 0.77 | ALDH1A1 (0.50) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |