Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485274 | 0.79 | NPC1 (0.73) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL14076317 | 0.77 | LMNA (0.67) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL3796033 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL600508 | 0.77 | NPC1 (1.00) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL3293156 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNANPC1RAB9APOLB | |
| SCHEMBL10532248 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL3429462 | 0.75 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL3065316 | 0.74 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL3079520 | 0.74 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL26762334 | 0.72 | RAB9A (0.59) | SMN1; SMN2LMNAHTTMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127878-A2 | USE OF THIABENDAZOLE AND DERIVATIVES THEREOF FOR THE THERAPHY OF NEUROLOGICAL CONDITIONS | SYGNIS BIOSCIENCE GMBH & CO. KG (DE) | 2010-11-11 | — | — | WO | claimed |
| WO-2010127878-A2 | USE OF THIABENDAZOLE AND DERIVATIVES THEREOF FOR THE THERAPHY OF NEUROLOGICAL CONDITIONS | SYGNIS BIOSCIENCE GMBH & CO. KG (DE) | 2010-11-11 | — | — | WO | disclosed |