Sugi Predict

Sugi Predict / Compounds / SCHEMBL378947

SCHEMBL378947

SCHEMBL378947

O=C1c2ccccc2C(=O)N1Cc1cccc(CCl)n1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.58
▸ MEN1 O00255 1/20 0.58
▸ PKM P14618 1/20 0.58
▸ KMT2A Q03164 1/20 0.58
▸ NPSR1 Q6W5P4 1/20 0.49
▸ MAPT P10636 2/20 0.48
▸ RECQL P46063 1/20 0.48
▸ CASP3 P42574 2/20 0.47
▸ TYR P14679 3/20 0.45
▸ HSD17B10 Q99714 1/20 0.44
▸ CYP1B1 Q16678 1/20 0.44
▸ GLS O94925 1/20 0.43
▸ CA12 O43570 1/20 0.43
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43
▸ CA9 Q16790 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29575442 1.00 ALDH1A1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL8377843 0.91 ALDH1A1 (0.68) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL930355 0.83 KMT2A (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL14905034 0.83 ALDH1A1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL23796073 0.80 ALDH1A1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL2766815 0.80 MEN1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL1632535 0.80 ALDH1A1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL4882922 0.80 ALDH1A1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL5028346 0.80 ALDH1A1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1
SCHEMBL1072206 0.80 ALDH1A1 (0.58) ALDH1A1MEN1PKMKMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 — — US disclosed
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 — — US disclosed
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 — — US disclosed
EP-3978488-A1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Universitetet I Oslo (NO) 2022-04-06 — — EP disclosed
EP-3978488-A1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Universitetet I Oslo (NO) 2022-04-06 — — EP disclosed
CN-109952297-B Compound (I) 奥斯陆大学 2022-02-25 — — CN disclosed
US-20210221791-A1 COMPOUNDS UNIVERSITETET I OSLO (NO) 2021-07-22 — — US disclosed
EP-3497095-B1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION UNIV OSLO (NO) 2021-07-14 — — EP disclosed
EP-3497095-B1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION UNIV OSLO (NO) 2021-07-14 — — EP disclosed
US-10961223-B2 Compounds UNIVERSITETET I OSLO (NO) 2021-03-30 — — US disclosed
WO-2018033719-A1 COMPOUNDS UNIVERSITETET I OSLO (NO) 2018-02-22 — — WO disclosed
US-8778966-B2 Quinolinone derivatives as PARP and tank inhibitors JANSSEN PHARMACEUTICA, NV (BE) 2014-07-15 — — US disclosed
US-8466176-B2 Fungicide hydroximoyl-tetrazole derivatives BAYER CROPSCIENCE AG (DE) 2013-06-18 — — US disclosed
US-20130018017-A1 QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS VIALARD JORGE EDUARDO (BE) 2013-01-17 — — US disclosed
US-8299256-B2 Quinolinone derivatives as PARP and TANK inhibitors JANSSEN PHARMACEUTICA NV (BE) 2012-10-30 — — US disclosed
EP-2134691-B1 QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2012-01-25 — — EP disclosed
US-20110105566-A1 FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2011-05-05 — — US disclosed
EP-2265118-A2 FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES Bayer CropScience AG (DE) 2010-12-29 — — EP disclosed
US-20100168065-A1 QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-07-01 — — US disclosed
WO-2009115557-A2 FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES BAYER CROPSCIENCE SA (FR) 2009-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110105566-A1 FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES HAAO, CYP51A1, HPD ALDH1A1 3321/4885MEN1 1827/4885PKM 1898/4885
US-11649222-B2 Compounds SLC30A6, SLC39A11, SLC39A3 ALDH1A1 3235/4885MEN1 2831/4885PKM 2850/4885
US-10961223-B2 Compounds SLC30A6, SLC39A11, SLC30A5 ALDH1A1 2991/4885MEN1 2663/4885PKM 2571/4885
US-20100168065-A1 QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS PARP1, PARP11, PARP3 ALDH1A1 2041/4885MEN1 2135/4885PKM 905/4885
US-20130018017-A1 QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS PARP1, PARP11, PARP3 ALDH1A1 2041/4885MEN1 2135/4885PKM 905/4885
US-20210221791-A1 COMPOUNDS SLC30A6, SLC30A5, SLC39A11 ALDH1A1 4328/4885MEN1 2394/4885PKM 3373/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.