Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL379435 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL40882 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1458270 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL11906204 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL5471628 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL445486 | 0.97 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL7519368 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL379089 | 0.94 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569386 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569395 | 0.94 | CA4 (0.84) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962628-B2 | Use of citrate solution for affinity chromatographic purification of CRP using phosphocholine and derivatives thereof | PENTRACOR GMBH (DE) | 2018-05-08 | — | — | US | claimed |
| EP-3083665-B1 | USE OF A CITRATE SOLUTION FOR THE AFFINITY-CHROMATOGRAPHIC PURIFICATION OF CRP USING PHOSPHOCHOLIN AND ITS DERIVATIVES | PENTRACOR GMBH (DE) | 2018-01-10 | — | — | EP | claimed |
| US-20170319982-A1 | USE OF A CITRATE SOLUTION FOR AFFINITY CHROMATOGRAPHIC PURIFICATION OF CRP USING PHOSPHOCHOLINE AND DERIVATIVES THEREOF | PENTRACOR GMBH (DE) | 2017-11-09 | — | — | US | claimed |
| WO-2013028574-A2 | AQUEOUS LITHIUM AIR BATTERIES | POLYPLUS BATTERY COMPANY (US) | 2013-02-28 | — | — | WO | claimed |
| US-12390569-B2 | Simplified regeneration of apheresis columns | PENTRACOR GMBH (DE) | 2025-08-19 | — | — | US | disclosed |
| EP-3762065-B1 | SIMPLIFIED REGENERATION OF APHERESIS COLUMNS | PENTRACOR GMBH (DE) | 2025-04-16 | — | — | EP | disclosed |
| CN-115052677-B | Use of alkali metal hydroxide solutions for regeneration of single-column columns | 彭特科尔有限公司 | 2025-03-28 | — | — | CN | disclosed |
| WO-2023232096-A1 | AIR SPRAY BASED ON VIRUS BLOCKING AGENT, AND USE THEREOF | 康码（上海）生物科技有限公司 | 2023-12-07 | — | — | WO | disclosed |
| US-20230090960-A1 | USING AN ALKALIHYDROXIDE SOLUTION FOR THE REGENERATION OF AN APHERESIS COLUMN | PENTRACOR GMBH (DE) | 2023-03-23 | — | — | US | disclosed |
| CN-115181616-A | Nucleic acid scavenger based on virus blocking agent and application thereof | 康码（上海）生物科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-115052677-A | Use of alkali metal hydroxide solutions for the regeneration of extraction columns | 彭特科尔有限公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-114870061-A | Air spray based on virus blocking agent and application thereof | 康码（上海）生物科技有限公司 | 2022-08-09 | — | — | CN | disclosed |
| US-20130323489-A1 | PROCESS FOR PREPARING SURFACE-REACTED CALCIUM CARBONATE AND ITS USE | OMYA INTERNATIONAL AG (CH) | 2013-12-05 | — | — | US | disclosed |
| WO-2013028574-A2 | AQUEOUS LITHIUM AIR BATTERIES | POLYPLUS BATTERY COMPANY (US) | 2013-02-28 | — | — | WO | disclosed |
| US-20130045428-A1 | AQUEOUS LITHIUM AIR BATTERIES | POLYPLUS BATTERY COMPANY (US) | 2013-02-21 | — | — | US | disclosed |
| US-20120142965-A1 | FOR PREPARING SURFACE-REACTED CALCIUM CARBONATE AND ITS USE | OMYA INTERNATIONAL AG (CH) | 2012-06-07 | — | — | US | disclosed |
| EP-2264109-B1 | Process for preparing surface-reacted calcium carbonate and its use | OMYA DEVELOPMENT AG (CH) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010146531-A1 | PROCESS FOR PREPARING SURFACE-REACTED CALCIUM CARBONATE AND ITS USE | OMYA DEVELOPMENT AG (CH) | 2010-12-23 | — | — | WO | disclosed |
| EP-2264109-A1 | Process for preparing surface-reacted calcium carbonate and its use | Omya Development AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| US-5453472-A | Antideposit agents for polymerization reactor walls | BASF AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170319982-A1 | USE OF A CITRATE SOLUTION FOR AFFINITY CHROMATOGRAPHIC PURIFICATION OF CRP USING PHOSPHOCHOLINE AND DERIVATIVES THEREOF | PHOSPHO1, ACP1, ALB | CA4 353/4885ALDH1A1 4682/4885CASP1 2925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.